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Appl Environ Microbiol. 1974 April; 27(4): 777-783
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Production of a Potent Vaccine from the Attenuated M-44 Strain of Coxiella burneti

David M. Robinson and Sherman E. Hasty

1 U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701

ABSTRACT

The attenuated M-44 strain of Coxiella burneti was heated to free it of adventitious agents that may have been present. Parallel titrations of the strain before and after heating indicated that the virulence for guinea pigs was markedly decreased. Guinea pigs immunized with the strain derived after heat treatment were protected from the effects of challenge with C. burneti in either phase I or II.

Appl Environ Microbiol. 1974 April; 27(4): 777-783
Copyright © 1974 American Society for Microbiology. All Rights Reserved.





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Copyright © 1974 by the American Society for Microbiology. All rights reserved.