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Appl Environ Microbiol. 1974 July; 28(1): 26-30
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Influence of Viral Envelope on Newcastle Disease Virus Infection¹

Department of Microbiology, Emory University, Atlanta, Georgia 30322

ABSTRACT

The adsorption characteristics of Newcastle disease virus (NDV) propagated in chicken cells (NDV-C) and in human cells (NDV-H) were examined. Adsorption experiments performed at different temperatures indicated that virus propagated in a particular cell infected that cell type more readily than did virus propagated in a different host. For example, NDV-C was more efficient in initiating infection of chicken cells at 22 C than was NDV-H; the reverse was true when human cells were employed. The results indicate that infection of susceptible cells by NDV is influenced by the host cell in which the virus was propagated. The data also suggest that NDV may be useful in studies on homologous and heterologous membrane-membrane interactions.

¹ Publication no. 1204, Division of Basic Health Science, Emory University, Atlanta, Ga. 30322.