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Appl Environ Microbiol. 1974 July; 28(1): 52-57
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Step of Dichlorvos Inhibition in the Pathway of Aflatoxin Biosynthesis

Department of Environmental Toxicology, University of California, Davis, California 95616

ABSTRACT

Dichlorvos (dimethyl 2,2-dichlorovinyl phosphate) inhibits the biosynthesis of aflatoxin by Aspergillus parasiticus. Cultures treated with dichlorvos excrete an orange pigment which can be converted into aflatoxin B₁ by the untreated mycelia. The orange pigment was partially identified as an acetyl derivative of versiconol-type compound. In the presence of dichlorvos, sterigmatocystin is converted into aflatoxin B₁ without being interfered, but averufin is converted into the orange pigment instead of aflatoxin B₁. Therefore, dichlorvos appears to block an enzymatic step in the aflatoxin biosynthetic pathway, which lies beyond averufin but before sterigmatocystin, at the formation of the orange pigment.