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Appl Environ Microbiol. 1974 November; 28(5): 881-884
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Virulence of Venezuelan Equine Encephalomyelitis Virus Subtypes for Various Laboratory Hosts

Arbovirology Section, Center for Disease Control, Atlanta, Georgia 30333

ABSTRACT

Mice, guinea pigs, and duck embryo cell cultures were inoculated with known subtypes of Venezuelan equine encephalomyelitis (VEE) virus and the attenuated (TC-83) strain of VEE. With the exception of TC-83, all strains were highly pathogenic for suckling mice by either intracranial or intraperitoneal routes of inoculation used. Virulence for older mice and guinea pigs provided a means to distinguish strains. In addition, virulence or lack of virulence for adult mice or guinea pigs provides a rapid method for separating epizootic subtype IB from TC-83 VEE virus isolates.

¹ Present address: Vector-Borne Diseases Branch, Bureau of Laboratories, Center for Disease Control, P.O. Box 2087, Foothills Campus, Fort Collins, Colo. 80521.