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Appl Environ Microbiol. 1974 December; 28(6): 995-998
Copyright © 1975 American Society for Microbiology. All Rights Reserved.

Microbial Transformation of Methyl 5(6)-Butyl-2-Benzimidazolecarbamate

J. R. Valenta, C. J. DICuollo, L. R. Fare, J. A. Miller and J. F. Pagano

Research and Development Division, Smith Kline and French Laboratories, Philadelphia, Pennsylvania 19101

ABSTRACT

The anthelmintic agent methyl 5(6)-butyl-2-benzimidazolecarbamate (Parbendazole) was transformed to two of its animal metabolites, methyl 5(6)-(4-hydroxybutyl)-2-benzimidazolecarbamate and methyl 5(6)-3-(carboxypropyl)-2-benzimidazolecarbamate, by the filamentous fungus Cunninghamella bainieri ATCC 9244. The transformation pathway was shown to be through the 4-hydroxybutyl product to the 3-carboxypropyl product. The reaction favored accumulation of the latter product.

Appl Environ Microbiol. 1974 December; 28(6): 995-998
Copyright © 1975 American Society for Microbiology. All Rights Reserved.





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Copyright © 1974 by the American Society for Microbiology. All rights reserved.