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Appl Environ Microbiol. 1977 April; 33(4): 814-816

Production of [14C]patulin by Penicillium patulum.

W K Nip and F S Chu

ABSTRACT

Factors affecting the production of [14C]patulin from [1-14C]acetate by replacement cultures of Penicillium patulum have been investigated. Incorporation of [1-14C]acetate into patulin reached a maximum with 6- to 8-day-old cultures incubated at 28 degrees C for 8 h in a replacement medium containing 0.1 M glucose, inorganic salts, and undiluted [1-14C]acetate. The specific activity of [14C]patulin obtained from this method was 34 mCi/mmol when 0.5 mCi of [1-14C]acetate was supplied to the replacement medium.

Appl Environ Microbiol. 1977 April; 33(4): 814-816






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