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Appl Environ Microbiol. 1978 June; 35(6): 1074-1078

Production of cyclochlorotine and a new metabolite, simatoxin, by Penicillium islandicum Sopp.

A C Ghosh, A Manmade, J M Townsend, A Bousquet, J F Howes and A L Demain

ABSTRACT

Production of the hepatotoxin cyclochlorotine by Penicillium islandicum was studied under a variety of fermentation conditions. The best system for production was agitated red wheat. A thin-layer chromatographic method was developed for the detection of this cyclic polypeptide. These experiments have resulted in the isolation of a new toxic metabolite, which we call simatoxin.

Appl Environ Microbiol. 1978 June; 35(6): 1074-1078






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