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Appl Environ Microbiol. 1978 September; 36(3): 412-420

Mollicellins: mutagenic and antibacterial mycotoxins.

A A Stark, B Kobbe, D Matsuo, G Büchi, G N Wogan and A L Demain

ABSTRACT

Eight mollicellins (depsidones) were assayed for mutagenicity and antibacterial activity in Salmonella/microsome tests involving histidine reversion and forward mutation to 8-azaguanine resistance. Two of them, mollicellins C and E, which contain a 3-methylbutenoic acid moiety, were mutagenic and bactericidal for Salmonella typhimurium in the absence of microsomes. Mollicellins D and F, each containing a chlorine atom, were bactericidal but not mutagenic. The mutagenic activity was completely abolished and the antibiotic activity was greatly reduced by coincubation with rat liver microsomes.

Appl Environ Microbiol. 1978 September; 36(3): 412-420






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