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Appl Environ Microbiol. 1979 January; 37(1): 11-13

Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity.

ABSTRACT

Fusarium moniliforme NRRL 6322 produced about 600 mg of recoverable moniliformin, a mycotoxic metabolite, per kg of corn grit medium. The moniliformin was extracted from the grits with methanol, purified by preparative thin-layer chromatography, and crystallized from ether. The 50% lethal dose for chicken embryos was 2.8 microgram per egg. For 1-day-old chicks dosed with moniliformin by crop intubation and for female and male mice injected intraperitoneally, the 50% lethal doses were 5.4, 20.9, and 29.1 mg per kg of body weight, respectively. The toxin did not cause a reaction on mouse skin.

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• Fotso, J., Leslie, J. F., Smith, J. S. (2002). Production of Beauvericin, Moniliformin, Fusaproliferin, and Fumonisins B1, B2, and B3 by Fifteen Ex-Type Strains of Fusarium Species. Appl. Environ. Microbiol. 68: 5195-5197 [Abstract] [Full Text]