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Appl Environ Microbiol. 1979 February; 37(2): 222-226

Conversion of 2,4,6-trinitrophenol to a mutagen by Pseudomonas aeruginosa.

J F Wyman, H E Guard, W D Won and J H Quay

ABSTRACT

A strain of Pseudomonas aeruginosa reduced 2,4,6-trinitrophenol (picric acid) to 2-amino-4,6-dinitrophenol (picramic acid) under anaerobic conditions. Mutagenic assays of picric acid and picramic acid were carried out with histidine-requiring strains of Salmonella typhimurium. Picric acid (10 micrograms per plate) demonstrated mutagenicity (both frame shift and base substitution-gype mutations) only after activation with a rat liver homogenate preparation. Picramic acid (1 microgram per plate) induced both base pair substitution and frame shift-tupe mutations without activation by the rat liver preparation.

Appl Environ Microbiol. 1979 February; 37(2): 222-226






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