This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ward, R L Articles by Ashley, C S Search for Related Content PubMed PubMed Citation Articles by Ward, R L Articles by Ashley, C S Agricola Articles by Ward, R L Articles by Ashley, C S

 Previous Article  |  Next Article 

Appl Environ Microbiol. 1979 August; 38(2): 314-322

pH modification of the effects of detergents on the stability of enteric viruses.

ABSTRACT

The effect of detergents on the stability of enteric viruses was found to be highly dependent on pH. This was demonstrated primarily with two ionic detergents, sodium dodecyl sulfate (an anionic detergent) and dodecyltrimethylammonium chloride (a cationic detergent). Both detergents were shown to be potent virucidal agents for reovirus, but the effects of sodium dodecyl sulfate were minimal near neutrality and much more pronounced at low than at high pH values. Dodecyltrimethylammonium chloride was extremely virucidal at high pH's but had little observable effect on reovirus stability at low pH values. In contrast, both detergents protected enteroviruses against heat at neutral and alkaline pH's. However, as was found with reovirus, sodium dodecyl sulfate was extremely virucidal at pH values below 5, even when the virus samples were incubated in ice. At different pH's the effects of detergents on the stabilities of coliphages T4, f1, and Q beta were qualitatively similar to those found with reovirus. Differences in viral stability in these experiments appeared to be due to the effects of pH on the ionic states of the viral capsid proteins.

This article has been cited by other articles:

• Bestman-Smith, J., Piret, J., Desormeaux, A., Tremblay, M. J., Omar, R. F., Bergeron, M. G. (2001). Sodium Lauryl Sulfate Abrogates Human Immunodeficiency Virus Infectivity by Affecting Viral Attachment. Antimicrob. Agents Chemother. 45: 2229-2237 [Abstract] [Full Text]  
• Roy, S., Gourde, P., Piret, J., Désormeaux, A., Lamontagne, J., Haineault, C., Omar, R. F., Bergeron, M. G. (2001). Thermoreversible Gel Formulations Containing Sodium Lauryl Sulfate or n-Lauroylsarcosine as Potential Topical Microbicides against Sexually Transmitted Diseases. Antimicrob. Agents Chemother. 45: 1671-1681 [Abstract] [Full Text]  
• Piret, J., Désormeaux, A., Cormier, H., Lamontagne, J., Gourde, P., Juhász, J., Bergeron, M. G. (2000). Sodium Lauryl Sulfate Increases the Efficacy of a Topical Formulation of Foscarnet against Herpes Simplex Virus Type 1 Cutaneous Lesions in Mice. Antimicrob. Agents Chemother. 44: 2263-2270 [Abstract] [Full Text]  
• Piret, J., Lamontagne, J., Bestman-Smith, J., Roy, S., Gourde, P., Désormeaux, A., Omar, R. F., Juhász, J., Bergeron, M. G. (2000). In Vitro and In Vivo Evaluations of Sodium Lauryl Sulfate and Dextran Sulfate as Microbicides against Herpes Simplex and Human Immunodeficiency Viruses. J. Clin. Microbiol. 38: 110-119 [Abstract] [Full Text]