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Appl Environ Microbiol. 1980 July; 40(1): 102-107

Evaluation of Bone Strength During Aflatoxicosis and Ochratoxicosis

¹ Department of Poultry Science, North Carolina State University, Raleigh, North Carolina 27650
² Department of Food Science, North Carolina State University, Raleigh, North Carolina 27650
³ Northern Regional Center, Agricultural Research, Science Education Administration, U.S. Department of Agriculture, Peoria, Illinois 61604

ABSTRACT

Young chickens were fed graded levels of aflatoxin (0, 0.625, 1.25, 2.5, 5.0, and 10.0 µg/g of diet) or ochratoxin (0, 0.5, 1.0, 2.0, 4.0, and 8.0 µg/g of diet), and the breaking strength, displacement before failure, and diameter of their tibias were determined. Breaking strength was decreased at growth inhibitory levels of aflatoxin (2.5 µg/g) and ochratoxin (2 µg/g), whereas a reduction in diameter required higher levels (5.0 and 4.0 µg/g, respectively). Bones from birds with ochratoxicosis selected to have diameters equal to control bones had lower breaking strength. In an attempt to negate mathematically the effect of decreased diameter and bias in any selection process, stress at time of failure of the bones was calculated and found to be decreased by feeding aflatoxin but not ochratoxin. Total displacement of bones before breaking was increased significantly (P < 0.05) by both toxins at the highest levels administered, but this increase was primarily the result of an increase in displacement from the start of failure to complete failure. Increased displacement associated with both toxicoses was equal in bones selected to be of equal diameter or in bones from the same treatment but of different diameters. However, calculation of modulus of elasticity which is corrected for diameter revealed aflatoxin had no effect whereas ochratoxin tripled the effect. These data indicate that the material properties of bones can be altered during mycotoxicoses and suggest yet another way in which mycotoxins are detrimental to animal health.

Paper number 5989 of the Journal Series of the North Carolina Agriculture Experiment Station, Raleigh, N.C.