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Appl Environ Microbiol. 1980 October; 40(4): 706-709

Biosynthesis of versicolorin A.

M S Anderson and M F Dutton

ABSTRACT

The incorporation of various potential intermediates into versicolorin A by a versicolorin A-accumulating mutant of Aspergillus parasiticus was studied. Both whole mycelium and cell-free extracts of this mutant were able to convert 14C-labeled versiconal hemiacetal acetate to versicolorin A. By the use of a labeled double substrate technique it was shown that two other compounds, versicolorin A hemiacetal and its acetate derivative, were also converted to versicolorin A. It is concluded that one or both of these compounds are intermediates in the biosynthesis of versicolorin A and therefore may possibly be involved in the biogenesis of the aflatoxins.

Appl Environ Microbiol. 1980 October; 40(4): 706-709






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