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Appl Environ Microbiol. 1982 October; 44(4): 1004-1006
Copyright © 1982, American Society for Microbiology. All Rights Reserved.

Inactivation of Glutamine Synthetase by Ammonia Shock in the Gram-Positive Bacterium Streptomyces cattleya

Richard Wax, Linda Synder and Louis Kaplan

Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065

ABSTRACT

In cultures of the gram-positive bacterium Streptomyces cattleya, a rapid inactivation of glutamine synthetase was seen after ammonia shock. pH activity curves for ammonia-shocked and control cultures are shown. A peak of glutamine synthetase activity was seen during fermentation for production of the antibiotic thienamycin.

Present address: Fermentation Program, Frederick Cancer Research NCI-Facility, Frederick, MD 21701.