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Appl Environ Microbiol. 1983 May; 45(5): 1575-1581
Copyright © 1983, American Society for Microbiology. All Rights Reserved.

Novel Haloperoxidase Reaction: Synthesis of Dihalogenated Products

Cetus Corporation, Berkeley, California 94710

ABSTRACT

The enzymatic synthesis of vicinal, dihalogenated products from alkenes and alkynes is described. The enzymatic reaction required an alkene or alkyne, dilute hydrogen peroxide, a haloperoxidase, and molar amounts of halide ions. Vicinal dichloro, dibromo, and diiodo products could be formed. A hydroxyl group on the carbon adjacent to the carbon-carbon double or triple bond lowered the halide ion concentration needed to produce the dihalo product. This reaction offers one explanation for the origin of natural, vicinal, dihalogenated products, such as those found frequently in marine microogranisms.