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Appl Environ Microbiol. 1984 February; 47(2): 239-244
Copyright © 1984, American Society for Microbiology. All Rights Reserved.

Application of a Microcomputer-Based System to Control and Monitor Bacterial Growth

Jeffrey A. Titus{dagger}, Gregory W. Luli{ddagger}, Michael L. Dekleva and William R. Strohl*

Department of Microbiology, The Ohio State University, Columbus, Ohio 43210

ABSTRACT

A modular microcomputer-based system was developed to control and monitor various modes of bacterial growth. The control system was composed of an Apple II Plus microcomputer with 64-kilobyte random-access memory; a Cyborg ISAAC model 91A multichannel analog-to-digital and digital-to-analog converter; paired MRR-1 pH, pO2, and foam control units; and in-house-designed relay, servo control, and turbidimetry systems. To demonstrate the flexibility of the system, we grew bacteria under various computer-controlled and monitored modes of growth, including batch, turbidostat, and chemostat systems. The Apple-ISAAC system was programmed in Labsoft BASIC (extended Applesoft) with an average control program using ca. 6 to 8 kilobytes of memory and up to 30 kilobytes for datum arrays. This modular microcomputer-based control system was easily coupled to laboratory scale fermentors for a variety of fermentations.

FOOTNOTES

* Corresponding author.

{dagger} Present address: Bristol Laboratories, Syracuse, NY 13221.

{ddagger} Present address: Battelle Columbus Laboratories, Columbus, OH 43210.

Appl Environ Microbiol. 1984 February; 47(2): 239-244
Copyright © 1984, American Society for Microbiology. All Rights Reserved.





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Copyright © 1984 by the American Society for Microbiology. All rights reserved.