This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hawkins, P R Articles by Falconer, I R Search for Related Content PubMed PubMed Citation Articles by Hawkins, P R Articles by Falconer, I R Agricola Articles by Hawkins, P R Articles by Falconer, I R

 Previous Article  |  Next Article 

Appl Environ Microbiol. 1985 November; 50(5): 1292-1295

Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir.

P R Hawkins, M T Runnegar, A R Jackson and I R Falconer

ABSTRACT

Cylindrospermopsis raciborskii, a tropical blooming species of cyanobacterium (blue-green alga), was isolated from the domestic water supply reservoir on Palm Island, a continental island off the tropical northeast coast of Australia. This species, not previously known to be toxic, was shown to be severely hepatotoxic for mice. The 50% lethal dose at 24 h after injection was found to be 64 +/- 5 mg of freeze-dried culture per kg of mouse. The principal lesion produced was centrilobular to massive hepatocyte necrosis, but various degrees of injury were also seen in the kidneys, adrenal glands, lungs, and intestine. The possible implication of this finding in relation to an incident of hepatoenteritis in humans living on the island is discussed.

---

Appl Environ Microbiol. 1985 November; 50(5): 1292-1295

This article has been cited by other articles:

• Hedman, C. J., Krick, W. R., Karner Perkins, D. A., Harrahy, E. A., Sonzogni, W. C. (2008). New Measurements of Cyanobacterial Toxins in Natural Waters Using High Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry. J. Environ. Qual. 37: 1817-1824 [Abstract] [Full Text]  
• Reisner, M., Carmeli, S., Werman, M., Sukenik, A. (2004). The Cyanobacterial Toxin Cylindrospermopsin Inhibits Pyrimidine Nucleotide Synthesis and Alters Cholesterol Distribution in Mice. Toxicol Sci 82: 620-627 [Abstract] [Full Text]  
• Runnegar, M. T., Xie, C., Snider, B. B., Wallace, G. A., Weinreb, S. M., Kuhlenkamp, J. (2002). In Vitro Hepatotoxicity of the Cyanobacterial Alkaloid Cylindrospermopsin and Related Synthetic Analogues. Toxicol Sci 67: 81-87 [Abstract] [Full Text]  
• Saker, M. L., Neilan, B. A. (2001). Varied Diazotrophies, Morphologies, and Toxicities of Genetically Similar Isolates of Cylindrospermopsis raciborskii (Nostocales, Cyanophyceae) from Northern Australia. Appl. Environ. Microbiol. 67: 1839-1845 [Abstract] [Full Text]  
• Wilson, K. M., Schembri, M. A., Baker, P. D., Saint, C. P. (2000). Molecular Characterization of the Toxic Cyanobacterium Cylindrospermopsis raciborskii and Design of a Species-Specific PCR. Appl. Environ. Microbiol. 66: 332-338 [Abstract] [Full Text]  
• (1998). Proceedings of the British Toxicology Society Annual Congress University of Surrey, Guildford 19 - 22 April 1998. Hum Exp Toxicol 17: 469-534