This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McCormick, S P Articles by Lee, L S Search for Related Content PubMed PubMed Citation Articles by McCormick, S P Articles by Lee, L S Agricola Articles by McCormick, S P Articles by Lee, L S

 Previous Article  |  Next Article 

Appl Environ Microbiol. 1987 January; 53(1): 14-16

Averufanin is an aflatoxin B1 precursor between averantin and averufin in the biosynthetic pathway.

ABSTRACT

Wild-type Aspergillus parasiticus produces, in addition to the colorless aflatoxins, a number of pigmented secondary metabolites. Examination of these pigments demonstrated that a major component was an anthraquinone, averufanin. Radiolabeling studies with [14C]averufanin showed that 23% of the label was incorporated into aflatoxin B1 by the wild type and that 31% of the label was incorporated into O-methylsterigmatocystin by a non-aflatoxin-producing isolate. In similar studies with blocked mutants of A. parasiticus the 14C label from averufanin was accumulated in averufin (72%) and versicolorin A (54%) but not averantin. The results demonstrate that averufanin is a biosynthetic precursor of aflatoxin B1 between averantin and averufin.

This article has been cited by other articles:

• Sakuno, E., Yabe, K., Nakajima, H. (2003). Involvement of Two Cytosolic Enzymes and a Novel Intermediate, 5'-Oxoaverantin, in the Pathway from 5'-Hydroxyaverantin to Averufin in Aflatoxin Biosynthesis. Appl. Environ. Microbiol. 69: 6418-6426 [Abstract] [Full Text]  
• Chang, P.-K., Yu, J., Ehrlich, K. C., Boue, S. M., Montalbano, B. G., Bhatnagar, D., Cleveland, T. E. (2000). adhA in Aspergillus parasiticus Is Involved in Conversion of 5'-Hydroxyaverantin to Averufin. Appl. Environ. Microbiol. 66: 4715-4719 [Abstract] [Full Text]  
• Keller, N. P., Watanabe, C. M. H., Kelkar, H. S., Adams, T. H., Townsend, C. A. (2000). Requirement of Monooxygenase-Mediated Steps for Sterigmatocystin Biosynthesis by Aspergillus nidulans. Appl. Environ. Microbiol. 66: 359-362 [Abstract] [Full Text]