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Appl Environ Microbiol. 1987 February; 53(2): 463-465
Copyright © 1987, American Society for Microbiology. All Rights Reserved.

Ethanol Perturbs Glycosylation and Inhibits Hypersecretion in Trichoderma reesei

Hannele Merivuori{dagger}, Bland S. Montenecourt and Jeffrey A. Sands{ddagger},*

Department of Biology, Lehigh University, Bethlehem, Pennsylvania 18015

ABSTRACT

The effects of ethanol and phenylethanol on the growth of and glycoprotein secretion by Trichoderma reesei were studied. Low levels (1.5%, vol/vol) of ethanol perturbed the glycosylation process, as shown by alterations in the isoelectric profile of the secreted proteins and a reduction in the rate of incorporation of mannose into oligosaccharides. In addition to these effects on posttranslational modification, ethanol drastically lowered the protein secretion level of a hypersecretory strain.

FOOTNOTES

* Corresponding author.

{dagger} Present address: Biotechnical Laboratory, Technical Research Centre of Finland, Tietotie 2, SF-02150 Espoo, Finland.

{ddagger} Present address: Recombinant DNA Laboratory, University of Helsinki, Valimotie 7, SF-00380 Helsinki 38, Finland.

Appl Environ Microbiol. 1987 February; 53(2): 463-465
Copyright © 1987, American Society for Microbiology. All Rights Reserved.





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