This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hartman, P. E. Articles by Stack, M. E. Search for Related Content PubMed PubMed Citation Articles by Hartman, P. E. Articles by Stack, M. E. Agricola Articles by Hartman, P. E. Articles by Stack, M. E.

 Previous Article  |  Next Article 

Appl Environ Microbiol. 1989 January; 55(1): 7-10
Copyright © 1989, American Society for Microbiology. All Rights Reserved.

Photodynamic Production of Superoxide In Vitro by Altertoxins in the Presence of Reducing Agents

Philip E. Hartman^*, Carolyn K. Suzuki and Michael E. Stack

¹ Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, and Division of Contaminants Chemistry, Food and Drug Administration, Washington, DC 20204²

ABSTRACT

Superoxide production by the three 4,9-dihydroxyperylene-3,10-quinone fungal toxins, altertoxins I, II, and III, was stimulated on illumination with broad-spectrum light. As determined previously for cercosporin, superoxide production by illuminated altertoxins was increased by the addition of the reducing substances ergothioneine or urate; ascorbate also effectively increased superoxide production. Illuminated urate alone engendered some superoxide production.

---

FOOTNOTES

^* Corresponding author.

Contribution 1419 of the Department of Biology, The Johns Hopkins University, Baltimore, MD 21218.

---

Appl Environ Microbiol. 1989 January; 55(1): 7-10
Copyright © 1989, American Society for Microbiology. All Rights Reserved.