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Appl Environ Microbiol. 1989 November; 55(11): 3029-3031

O dealkylation and aliphatic and aromatic hydroxylation of 3-methoxy-17 beta-estradiol by Aspergillus alliaceus.

J S Williamson, D E Van Orden and J P Rosazza

Biocatalysis Research Group, College of Pharmacy, University of Iowa, Iowa City 52242.

ABSTRACT

Aspergillus alliaceus UI 315 was examined for its ability to metabolize 3-methoxy-17 beta-estradiol. Preparative-scale incubations with this substrate afforded good yields of 6 beta-hydroxy-17 beta-estradiol, 4-hydroxy-17 beta-estradiol, and 4,6 beta-dihydroxy-17 beta-estradiol, which were identified by high-pressure liquid chromatography, 1H and 13C nuclear magnetic resonance, and high-resolution mass spectrometry.

Appl Environ Microbiol. 1989 November; 55(11): 3029-3031






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