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Appl Environ Microbiol. 1989 September; 55(9): 2275-2279

Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans.

National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079.

ABSTRACT

The metabolism of phenanthrene by the fungus Cunninghamella elegans was investigated. Kinetic experiments using [9-14C]phenanthrene showed that after 72 h, 53% of the total radioactivity was associated with a glucoside conjugate of 1-hydroxyphenanthrene (phenanthrene 1-O-beta-glucose). This metabolite was isolated by reversed-phase high-performance liquid chromatography and characterized by the application of UV absorption, 1H nuclear magnetic resonance, and mass spectral techniques. The results show that aromatic ring oxidation followed by glucosylation is a predominant pathway in the metabolism of the polycyclic aromatic hydrocarbon phenanthrene by C. elegans.

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