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Appl Environ Microbiol. 1990 November; 56(11): 3482-3484

Effect of aflatoxins on rat peritoneal macrophages.

V Cusumano, G B Costa and S Seminara

Microbiology Institute, Medical School, University of Messina, Italy.

ABSTRACT

Phagocytosis, intracellular killing of Candida albicans, and superoxide production by rat peritoneal macrophages exposed to aflatoxins B1, B2, G1, G2, B2a, and M1 at several times and concentrations were analyzed to evaluate the intensity of a depressive effect for each mycotoxin. All aflatoxins used at very low concentrations had a depressive effect on the functions of macrophages. The biggest impairment of phagocytosis, intracellular killing, and spontaneous superoxide production was observed in macrophages exposed to aflatoxins B1 and M1.

Appl Environ Microbiol. 1990 November; 56(11): 3482-3484






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