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Appl Environ Microbiol. 1991 July; 57(7): 2101-2103

Cytotoxicity of T-2 toxin and its metabolites determined with the neutral red cell viability assay.

Laboratory Animal Research Center, Rockefeller University, New York, New York 10021.

ABSTRACT

The neutral red (NR) cell viability assay was used with various cell types of human origin to quantitate the potency of T-2 mycotoxin and its metabolites. The human melanoma SK-Mel/27 cell line was the most sensitive, with a midpoint cytotoxicity value of 2.8 ng of T-2 per ml. With the human hepatoma cell line, HepG2, the sequence of potency for a series of mycotoxins was T-2 greater than HT-2 greater than T-2 triol greater than T-2 tetraol.

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