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Appl Environ Microbiol. 1993 November; 59(11): 3661-3665

Dose response of Cryptosporidium parvum in outbred neonatal CD-1 mice.

G R Finch, C W Daniels, E K Black, F W Schaefer 3rd and M Belosevic

Department of Civil Engineering, University of Alberta, Edmonton, Canada.

ABSTRACT

Cryptosporidium parvum infectivity in a neonatal CD-1 mouse model was used to determine the dose needed to infect 50% of the population. The 50% infective dose was estimated to be 79 oocysts. It was observed that a mean oral inoculum of 23 oocysts produced infection in 2 of 25 neonatal mice 7 days postinoculation. All animals became infected when the mean oral dose exceeded 310 oocysts per animal. The dose response of C. parvum was modeled with a logit dose-response model suitable for use in water disinfection studies.

Appl Environ Microbiol. 1993 November; 59(11): 3661-3665




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