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Appl. Environ. Microbiol., Oct 1996, 3864-3867, Vol 62, No. 10
Copyright © 1996, American Society for Microbiology

Involvement of carnitine acyltransferases in peroxisomal fatty acid metabolism by the yeast Pichia guilliermondii

Y Pagot and JM Belin
Laboratoire de Biotechnologie, Ecole Nationale Superieure de Biologie Appliquee a la Nutrition et a l'Alimentation, Campus Universitaire Montmuzard, Dijon, France.

This article provides information about peroxisomal fatty acid metabolism in the yeast Pichia guilliermondii. The existence of inducible mitochondrial carnitine palmitoyltransferase and peroxisomal carnitine octanoyl-transferase activities was demonstrated after culture of this yeast in a medium containing methyl oleate. The subcellular sites and induction patterns were studied. The inhibition of carnitine octanoyl- and palmitoyl-transferases by chlorpromazine to a large extent prevented the otherwise observed metabolism-dependent inactivation of thiolase by 2-bromofatty acids in vivo. We concluded that the metabolism of long- and medium-chain fatty acids in the peroxisome of this yeast involved carnitine intermediates.

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