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Appl. Environ. Microbiol., Aug 1996, 2701-2709, Vol 62, No. 8
Copyright © 1996, American Society for Microbiology

Bactericidal Mode of Action of Plantaricin C

B Gonzalez, E Glaasker, ERS Kunji, AJM Driessen, JE Suarez and WN Konings
Department of Microbiology, University of Oviedo, 33006 Oviedo, Spain, and Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9751 NN Haren, The Netherlands

Plantaricin C is a bacteriocin produced by Lactobacillus plantarum LL441 that kills sensitive cells by acting on the cytoplasmic membrane. In contrast to its lack of impact on immune cells, plantaricin C dissipates the proton motive force and inhibits amino acid transport in sensitive cells. In proteoliposomes, plantaricin C dissipates the transmembrane electrical potential, and in liposomes, it elicits efflux of entrapped carboxy-fluorescein. It is concluded that plantaricin C is a pore-forming bacteriocin that functions in a voltage-independent manner and does not require a specific protein receptor in the target membrane.

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