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Applied and Environmental Microbiology, November 1998, p. 4482-4484, Vol. 64, No. 11
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Antifungal Metabolites (Monorden, Monocillin IV, and Cerebrosides) from Humicola fuscoatra Traaen NRRL 22980, a Mycoparasite of Aspergillus flavus Sclerotia

Donald T. Wicklow,1,* Biren K. Joshi,2 William R. Gamble,2 James B. Gloer,2 and Patrick F. Dowd1

Bioactive Agents Research, National Center for Agricultural Utilization Research, REE, Agricultural Research Service, U.S. Department of Agriculture, Peoria, Illinois 61604,1 and Department of Chemistry, University of Iowa, Iowa City, Iowa 522422

Received 18 May 1998/Accepted 3 September 1998

The mycoparasite Humicola fuscoatra NRRL 22980 was isolated from a sclerotium of Aspergillus flavus that had been buried in a cornfield near Tifton, Ga. When grown on autoclaved rice, this fungus produced the antifungal metabolites monorden, monocillin IV, and a new monorden analog. Each metabolite produced a clear zone of inhibition surrounding paper assay disks on agar plates seeded with conidia of A. flavus. Monorden was twice as inhibitory to A. flavus mycelium extension (MIC > 28 µg/ml) as monocillin IV (MIC > 56 µg/ml). Cerebrosides C and D, metabolites known to potentiate the activity of cell wall-active antibiotics, were separated from the ethyl acetate extract but were not inhibitory to A. flavus when tested as pure compounds. This is the first report of natural products from H. fuscoatra.

* Corresponding author. Mailing address: Bioactive Agents Research, REE, ARS, NCAUR, USDA, 1815 N. University St., Peoria, IL 61604. Phone: (309) 681-6243. Fax: (309) 681-6686. E-mail: wicklodt{at}mail.ncaur.usda.gov.

Applied and Environmental Microbiology, November 1998, p. 4482-4484, Vol. 64, No. 11
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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