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Applied and Environmental Microbiology, November 1998, p. 4596-4599, Vol. 64, No. 11
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Effect of Prior Exposure to Noninfected Ticks on Susceptibility of Mice to Lyme Disease Spirochetes

Dania Richter,1,2,* Andrew Spielman,1 and Franz-Rainer Matuschka1,2

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115,1 and Institut für Pathologie, Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin, Berlin, Germany2

Received 11 May 1998/Accepted 24 August 1998

To determine whether prior exposure to Nearctic Ixodes vector ticks protects native reservoir mice from tick-borne infection by Lyme disease spirochetes, we compared their infectivities for white-footed mice and laboratory mice that had been repeatedly infested by noninfected deer ticks. Nymphal ticks readily engorged on tick-exposed laboratory mice, but their feeding success on white-footed mice progressively declined. Tick-borne spirochetes readily infected previously tick-infested mice. Thus, prior infestation by Nearctic ticks does not protect sympatric reservoir mice or Palearctic laboratory mice from infection by sympatric tick-borne spirochetes.

* Corresponding author. Mailing address: Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115. Phone: (617) 432-1796. Fax: (617) 738-4914. E-mail: drichter{at}hsph.harvard.edu.

Applied and Environmental Microbiology, November 1998, p. 4596-4599, Vol. 64, No. 11
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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