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Applied and Environmental Microbiology, December 1998, p. 5061-5063, Vol. 64, No. 12
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Transfer of Streptomycin Biosynthesis Gene Clusters within Streptomycetes Isolated from Soil

Sharon Egan, Pamela Wiener, Dimitrios Kallifidas, and Elizabeth M. H. Wellington*

Department of Biological Sciences, University of Warwick, Coventry, United Kingdom CV4 7AL

Received 11 May 1998/Accepted 2 October 1998

Streptomyces strains isolated from soil were found to possess various numbers of genes from the streptomycin biosynthesis cluster. The strains missing genes from the cluster also lacked the ability to produce streptomycin. Two of the isolates which contain only part of the cluster are apparently recipients of a gene transfer event. The implications for the role of gene transfer in antibiotic evolution are discussed.

* Corresponding author. Mailing address: Department of Biological Sciences, University of Warwick, Coventry, United Kingdom CV4 7AL. Phone: (EMHW) 01203 523184. Fax: 01203 523701. E-mail: eg{at}dna.bio.warwick.ac.uk.

Applied and Environmental Microbiology, December 1998, p. 5061-5063, Vol. 64, No. 12
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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