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Appl Environ Microbiol, June 1998, p. 2275-2277, Vol. 64, No. 6
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Culture Conditions Control Expression of the Genes for Aflatoxin and Sterigmatocystin Biosynthesis in Aspergillus parasiticus and A. nidulans

Guo Hong Fengdagger and Thomas J. Leonard*

Department of Genetics, University of Wisconsin, Madison, Wisconsin 53706

Received 24 June 1997/Accepted 10 February 1998

High temperature and nitrate supported gene expression for sterigmatocystin biosynthesis in Aspergillus nidulans; ammonium did not. Homologous genes for aflatoxin biosynthesis in A. parasiticus showed the opposite transcript expression pattern, suggesting that the two mycotoxins are regulated differently. The aflR gene is postulated to require additional genetic elements to effect its own activation by the different culture conditions. A patulin polyketide synthase (PKS) gene was found to be regulated differently than the aflatoxin PKS. Thus, the biosyntheses of structurally similar compounds in these two fungi appear to be regulated very differently.

* Corresponding author. Present address: Department of Biology, Clark University, 950 Main St., Worcester, MA 01610. Phone: (508) 793-7107. Fax: (508) 793-8861. E-mail: tleonard{at}vax.clarku.edu.

dagger Present address: Department of Genetics, Stanford University Medical School, Stanford, CA 94305.

Appl Environ Microbiol, June 1998, p. 2275-2277, Vol. 64, No. 6
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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