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Applied and Environmental Microbiology, January 1999, p. 126-130, Vol. 65, No. 1
0099-2240/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

A Hemorrhagic Factor (Apicidin) Produced by Toxic Fusarium Isolates from Soybean Seeds

Jun-Suk Park,1 Kyung-Rim Lee,1 Jin-Cheol Kim,2 Sun-Hee Lim,1 Jeong-Ah Seo,1 and Yin-Won Lee1,*

Division of Applied Biology and Chemistry and Research Center for New Biomaterials in Agriculture, Seoul National University, Suwon 441-744,1 and Screening Division, Korea Research Institute of Chemical Technology, Taejon 305-600,2 Korea

Received 20 May 1998/Accepted 15 October 1998

Fifty-two isolates of Fusarium species were obtained from soybean seeds from various parts of Korea and identified as Fusarium oxysporum, F. moniliforme, F. semitectum, F. solani, F. graminearum, or F. lateritium. These isolates were grown on autoclaved wheat grains and examined for toxicity in a rat-feeding test. Nine cultures were toxic to rats. One of these, a culture of Fusarium sp. strain KCTC 16677, produced apicidin, an antiprotozoal agent that caused toxic effects in rats (including body weight loss; hemorrhage in the stomach, intestines, and bladder; and finally death) when rats were fed diets supplemented with 0.05 and 0.1% apicidin. The toxin was toxic to brine shrimp (the 50% lethal concentration was 40 µg/ml) and was weakly cytotoxic to human and mouse tumor cell lines.

* Corresponding author. Mailing address: Division of Applied Biology and Chemistry and Research Center for New Biomaterials in Agriculture, Seoul National University, Suwon 441-744, Korea. Phone: 82-331-290-2443. Fax: 82-331-294-5881. E-mail: lee2443{at}plaza.snu.ac.kr.

Applied and Environmental Microbiology, January 1999, p. 126-130, Vol. 65, No. 1
0099-2240/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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