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Applied and Environmental Microbiology, January 1999, p. 311-314, Vol. 65, No. 1
0099-2240/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Biosynthetic Pathway of Citrinin in the Filamentous Fungus Monascus ruber as Revealed by 13C Nuclear Magnetic Resonance

Hassan Hajjaj,1 Alain Klaébé,2 Marie O. Loret,1 Gérard Goma,1 Philippe J. Blanc,1 and Jean François1,*

Centre Bioingénierie Gilbert Durand, CNRS UMR 5504, LA INRA, Institut National des Sciences Appliquées de Toulouse, Complexe Scientifique de Rangueil,1 and Laboratoire IMRCP, UMR-CNRS 5623, Groupe de Chimie Organique Biologique, Université Paul Sabatier,2 Toulouse, France

Received 3 August 1998/Accepted 3 October 1998

Carbon isotope distribution of [13C]citrinin from Monascus ruber incubated with [13C]acetate revealed that the biosynthesis of the toxin originated from a tetraketide, instead of a pentaketide as has been shown for Penicillium and Aspergillus species. The production of polyketide red pigments and citrinin by M. ruber may therefore be regulated at the level of the tetraketide branch point.

* Corresponding author. Mailing address: Centre Bioingénierie Gilbert Durand, CNRS UMR 5504, LA INRA, Institut National des Sciences Appliquées de Toulouse, Complexe Scientifique de Rangueil, 31077 Toulouse, France. Phone: 33 5 61 55 94 92. Fax: 33 5 61 55 94 00. E-mail: fran_jm{at}insa-tlse.fr.

Applied and Environmental Microbiology, January 1999, p. 311-314, Vol. 65, No. 1
0099-2240/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Shimizu, T., Kinoshita, H., Nihira, T. (2007). Identification and In Vivo Functional Analysis by Gene Disruption of ctnA, an Activator Gene Involved in Citrinin Biosynthesis in Monascus purpureus. Appl. Environ. Microbiol. 73: 5097-5103 [Abstract] [Full Text]  
  • Shimizu, T., Kinoshita, H., Ishihara, S., Sakai, K., Nagai, S., Nihira, T. (2005). Polyketide Synthase Gene Responsible for Citrinin Biosynthesis in Monascus purpureus. Appl. Environ. Microbiol. 71: 3453-3457 [Abstract] [Full Text]  
  • Hajjaj, H., Klaébé, A., Goma, G., Blanc, P. J., Barbier, E., François, J. (2000). Medium-Chain Fatty Acids Affect Citrinin Production in the Filamentous Fungus Monascus ruber. Appl. Environ. Microbiol. 66: 1120-1125 [Abstract] [Full Text]  


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