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Applied and Environmental Microbiology, March 1999, p. 1356-1360, Vol. 65, No. 3
0099-2240/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Specific Genes for Lantibiotic Mutacin II Biosynthesis in Streptococcus mutans T8 Are Clustered and Can Be Transferred En Bloc

Ping Chen, FengXia Qi, Jan Novak, and Page W. Caufield*

Department of Oral Biology, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294

Received 3 September 1998/Accepted 14 December 1998

Mutacin II is a ribosomally synthesized peptide lantibiotic produced by group II Streptococcus mutans. DNA sequencing has revealed that the mutacin II biosynthetic gene cluster consists of seven specific open reading frames: a regulator (mutR), the prepromutacin structural gene (mutA), a modifying protein (mutM), an ABC transporter (mutT), and an immunity cluster (mutFEG). Transformations of a non-mutacin-producing strain, S. mutans UA159, and a mutacin I-producing strain, S. mutans UA140, with chromosomal DNA from S. mutans T8 with an aphIII marker inserted upstream of the mutacin II structural gene yielded transformants producing mutacin II and mutacins I and II, respectively.

* Corresponding author. Mailing address: LHRB 246, Department of Oral Biology, School of Dentistry, University of Alabama at Birmingham, 1919 7th Ave. South, Birmingham, AL 35294. Phone: (205) 934-4327. Fax: (205) 975-6773. E-mail: page{at}uab.edu.

Applied and Environmental Microbiology, March 1999, p. 1356-1360, Vol. 65, No. 3
0099-2240/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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