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Applied and Environmental Microbiology, May 1999, p. 2217-2221, Vol. 65, No. 5
0099-2240/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Anaerobic Dehalogenation of Hydroxylated Polychlorinated Biphenyls by Desulfitobacterium dehalogenans

Juergen Wiegel,* Xiaoming Zhang,dagger and Qingzhong WuDagger

Department of Microbiology, University of Georgia, Athens, Georgia 30602

Received 30 November 1998/Accepted 9 March 1999

Ten years after reports on the existence of anaerobic dehalogenation of polychlorinated biphenyls (PCBs) in sediment slurries, we report here on the rapid reductive dehalogenation of para-hydroxylated PCBs (HO-PCBs), the excreted main metabolites of PCB in mammals, which can exhibit estrogenic and antiestrogenic activities in humans. The anaerobic bacterium Desulfitobacterium dehalogenans completely dehalogenates all flanking chlorines (chlorines in ortho position to the para-hydroxyl group) from congeners such as 3,3',5,5'-tetrachloro-4,4'-dihydroxybiphenyl.

* Corresponding author. Mailing address: Department of Microbiology, University of Georgia, Cedar St., 215 Biological Sciences Bldg., Athens, GA 30602-2605. Phone and fax: (706) 542-2651. Fax: (706) 542-2674. E-mail: jwiegel{at}arches.uga.edu.

dagger Present address: Biotechnology Center for Agriculture and the Environment, Cook College, Rutgers University, New Brunswick, NJ 08903.

Dagger Present address: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425.

Applied and Environmental Microbiology, May 1999, p. 2217-2221, Vol. 65, No. 5
0099-2240/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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