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Applied and Environmental Microbiology, October 2000, p. 4536-4538, Vol. 66, No. 10
0099-2240/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Sulfur Regulation of the Sulfate Transporter Genes sutA and sutB in Penicillium chrysogenum

Mart van de Kamp,dagger Theo A. Schuurs,Dagger Arnold Vos,§ Ted R. van der Lende,|| Wil N. Konings, and Arnold J. M. Driessen*

Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9750 AA Haren, The Netherlands

Received 31 January 2000/Accepted 16 July 2000

Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB and sutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin.

* Corresponding author. Mailing address: Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, P.O. Box 14, 9750 AA Haren, The Netherlands.

dagger Present address: European Patent office, 2280 HV Rijswijk, The Netherlands.

Dagger Present address: Surgical Research Laboratory, Department of Surgery, University of Groningen, 9713 BZ Groningen, The Netherlands.

§ Present address: TNO-RUG Centre for Carbohydrate Bioengineering, 9750 AA Haren, The Netherlands.

|| Present address: TNO Voeding, 3700 AJ Zeist, The Netherlands.

Applied and Environmental Microbiology, October 2000, p. 4536-4538, Vol. 66, No. 10
0099-2240/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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