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Applied and Environmental Microbiology, October 2000, p. 4575-4578, Vol. 66, No. 10
0099-2240/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Phenylacetyl-Coenzyme A Is the True Inducer of the Phenylacetic Acid Catabolism Pathway in Pseudomonas putida U

Belén García,1 Elías R. Olivera,1 Baltasar Miñambres,1 David Carnicero,1 Carmen Muñiz,1 Germán Naharro,2 and José M. Luengo1,*

Departamento de Bioquímica y Biología Molecular1 and Departamento de Patología Animal (Sanidad Animal),2 Facultad de Veterinaria, Campus de Vegazana s/n, 24007 León, Spain

Received 12 May 2000/Accepted 17 July 2000

Aerobic degradation of phenylacetic acid in Pseudomonas putida U is carried out by a central catabolism pathway (phenylacetyl-coenzyme A [CoA] catabolon core). Induction of this route was analyzed by using different mutants specifically designed for this objective. Our results revealed that the true inducer molecule is phenylacetyl-CoA and not other structurally or catabolically related aromatic compounds.

* Corresponding author. Mailing address: Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Campus de Vegazana s/n, 24007 Leon, Spain. Phone: 34-87-291228. Fax: 34-87-291226. E-mail: dbbjlr{at}unileon.es.

Applied and Environmental Microbiology, October 2000, p. 4575-4578, Vol. 66, No. 10
0099-2240/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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