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Applied and Environmental Microbiology, June 2000, p. 2664-2667, Vol. 66, No. 6
0099-2240/00/$04.00+0

Microbiological Transformation of Enrofloxacin by the Fungus Mucor ramannianus

Igor A. Parshikov,1 James P. Freeman,2 Jackson O. Lay Jr.,2 Richard D. Beger,2 Anna J. Williams,1 and John B. Sutherland1,*

Division of Microbiology1 and Division of Chemistry,2 National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079

Received 14 December 1999/Accepted 21 March 2000

Enrofloxacin metabolism by Mucor ramannianus was investigated as a model for the biotransformation of veterinary fluoroquinolones. Cultures grown in sucrose-peptone broth were dosed with enrofloxacin. After 21 days, 22% of the enrofloxacin remained. Three metabolites were identified: enrofloxacin N-oxide (62% of the total absorbance), N-acetylciprofloxacin (8.0%), and desethylene-enrofloxacin (3.5%).

* Corresponding author. Mailing address: Division of Microbiology, National Center for Toxicological Research, Jefferson, AR 72079-9502. Phone: (870) 543-7059. Fax: (870) 543-7307. E-mail: jsutherland{at}nctr.fda.gov.

Applied and Environmental Microbiology, June 2000, p. 2664-2667, Vol. 66, No. 6
0099-2240/00/$04.00+0


This article has been cited by other articles:

  • Jung, C. M., Heinze, T. M., Deck, J., Strakosha, R., Sutherland, J. B. (2008). Transformation of N-Phenylpiperazine by Mixed Cultures from a Municipal Wastewater Treatment Plant. Appl. Environ. Microbiol. 74: 6147-6150 [Abstract] [Full Text]  
  • Parshikov, I. A., Moody, J. D., Freeman, J. P., Lay, J. O. Jr., Williams, A. J., Heinze, T. M., Sutherland, J. B. (2002). Formation of conjugates from ciprofloxacin and norfloxacin in cultures of Trichoderma viride. Mycologia 94: 1-5 [Abstract] [Full Text]  


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