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Applied and Environmental Microbiology, September 2000, p. 4142-4144, Vol. 66, No. 9
0099-2240/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Anhydrobiotic Engineering of Gram-Negative Bacteria

Arcadio García de Castro,1 Harald Bredholt,2 Arne R. Strøm,2 and Alan Tunnacliffe1,*

Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom,1 and Department of Biotechnology, Norwegian University of Science and Technology, N-7491 Trondheim, Norway2

Received 30 May 2000/Accepted 6 July 2000

Anhydrobiotic engineering aims to improve desiccation tolerance in living organisms by adopting the strategies of anhydrobiosis. This was achieved for Escherichia coli and Pseudomonas putida by osmotic induction of intracellular trehalose synthesis and by drying from trehalose solutions, resulting in long-term viability in the dried state.

* Corresponding author. Mailing address: Institute of Biotechnology, University of Cambridge, Tennis Court Rd., Cambridge CB2 1QT, United Kingdom. Phone: 44-1223-766549. Fax: 44-1223-334162. E-mail: at10004{at}biotech.cam.ac.uk.

Applied and Environmental Microbiology, September 2000, p. 4142-4144, Vol. 66, No. 9
0099-2240/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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