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Applied and Environmental Microbiology, February 2001, p. 1001-1003, Vol. 67, No. 2
Microbiology Group, Department of Biological
Sciences, Illinois State University, Normal, Illinois 61790-4120
Received 23 October 2000/Accepted 19 November 2000
To investigate iron uptake, a chromosomal locus containing three
consecutive open reading frames, designated fhuC,
fhuB, and fhuD, was identified in
Staphylococcus aureus. Whereas the fhuC gene
encodes an ATP-binding protein, fhuB and fhuD
code for ferrichrome permeases and thus resemble an ATP-binding
cassette transporter. A fhuB knockout mutant showed
impaired uptake of iron bound to the siderophores but not of ferric
chloride, suggesting that this operon is specific for
siderophore-mediated iron uptake.
0099-2240/01/$04.00+0 DOI: 10.1128/AEM.67.2.1001-1003.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Molecular Characterization of the Iron-Hydroxamate
Uptake System in Staphylococcus aureus


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Corresponding author. Mailing address: Microbiology
Group, Department of Biological Sciences, Illinois State University,
Normal, IL 61790-4120. Phone: (309) 438-5128. Fax: (309) 438-3722. E-mail: drjay{at}ilstu.edu.
Present address: CEACA, UAQ, Centro Universitario, Queretaro, Qro.
76010, Mexico.
Present address: Dept. of Microbiology and Immunology, Stanford
University School of Medicine, Stanford, CA 94305.
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