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Applied and Environmental Microbiology, May 2001, p. 2365-2366, Vol. 67, No. 5
0099-2240/01/$04.00+0   DOI: 10.1128/AEM.67.5.2365-2366.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Zeamatin Inhibits Trypsin and alpha -Amylase Activities

Rebecca Schimoler-O'Rourke,1 Michael Richardson,2 and Claude P. Selitrennikoff1,3,*

Mycologics, Inc.,1 and Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262,3 and Department of Biological Sciences, University of Durham, Durham, United Kingdom DH1 3LE2

Received 8 November 2000/Accepted 9 March 2001

Zeamatin is a 22-kDa protein isolated from Zea mays that has antifungal activity against human and plant pathogens. Unlike other pathogenesis-related group 5 proteins, zeamatin inhibits insect alpha -amylase and mammalian trypsin activities. It is of clinical significance that zeamatin did not inhibit human alpha -amylase activity and inhibited mammalian trypsin activity only at high molar concentrations.

* Corresponding author. Mailing address: Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, 4200 E. 9th Ave., Box B-111, Denver, CO 80262. Phone: (303) 315-8647. Fax: (303) 315-4024. E-mail: Claude.Selitrennikoff{at}uchsc.edu.

Applied and Environmental Microbiology, May 2001, p. 2365-2366, Vol. 67, No. 5
0099-2240/01/$04.00+0   DOI: 10.1128/AEM.67.5.2365-2366.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Selitrennikoff, C. P. (2001). Antifungal Proteins. Appl. Environ. Microbiol. 67: 2883-2894 [Full Text]  


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