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Applied and Environmental Microbiology, August 2001, p. 3716-3719, Vol. 67, No. 8
0099-2240/01/$04.00+0   DOI: 10.1128/AEM.67.8.3716-3719.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Transformation of 2,2'-Bimorphine to the Novel Compounds 10-alpha -S-Monohydroxy-2,2'-Bimorphine and 10,10'-alpha ,alpha '-S,S'-Dihydroxy-2,2'-Bimorphine by Cylindrocarpon didymum

Peter J. Stabler, Peter J. Holt, and Neil C. Bruce*

Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom

Received 16 January 2001/Accepted 17 May 2001

Whole-cell suspensions of Cylindrocarpon didymum were observed to transform 2,2'-bimorphine to the compounds 10-alpha -S-monohydroxy-2,2'-bimorphine and 10,10'-alpha ,alpha '-S,S'-dihydroxy-2,2'-bimorphine. Mass spectrometry and 1H nuclear magnetic resonance spectroscopy confirmed the identities of these new morphine alkaloids.

* Corresponding author. Mailing address: Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QT, United Kingdom. Phone: 44 (0) 1223 334168. Fax: 44 (0) 1223 334162. E-mail: n.bruce{at}biotech.cam.ac.uk.

Applied and Environmental Microbiology, August 2001, p. 3716-3719, Vol. 67, No. 8
0099-2240/01/$04.00+0   DOI: 10.1128/AEM.67.8.3716-3719.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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Copyright © 2001 by the American Society for Microbiology. All rights reserved.