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Applied and Environmental Microbiology, September 2001, p. 4358-4360, Vol. 67, No. 9
0099-2240/01/$04.00+0   DOI: 10.1128/AEM.67.9.4358-4360.2001

Biotransformation of Malachite Green by the Fungus Cunninghamella elegans

Chang-Jun Cha,1 Daniel R. Doerge,2 and Carl E. Cerniglia1,*

Division of Microbiology1 and Division of Biochemical Toxicology,2 National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079

Received 27 March 2001/Accepted 28 June 2001

The filamentous fungus Cunninghamella elegans ATCC 36112 metabolized the triphenylmethane dye malachite green with a first-order rate constant of 0.029 µmol h-1 (mg of cells)-1. Malachite green was enzymatically reduced to leucomalachite green and also converted to N-demethylated and N-oxidized metabolites, including primary and secondary arylamines. Inhibition studies suggested that the cytochrome P450 system mediated both the reduction and the N-demethylation reactions.

* Corresponding author. Mailing address: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502. Phone: (870) 543-7341. Fax: (870) 543-7307. E-mail: CCerniglia{at}nctr.fda.gov.

Applied and Environmental Microbiology, September 2001, p. 4358-4360, Vol. 67, No. 9
0099-2240/01/$04.00+0   DOI: 10.1128/AEM.67.9.4358-4360.2001


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