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Applied and Environmental Microbiology, October 2002, p. 4871-4875, Vol. 68, No. 10
0099-2240/02/$04.00+0     DOI: 10.1128/AEM.68.10.4871-4875.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Isolation and Identification of Aspergillus fumigatus Mycotoxins on Growth Medium and Some Building Materials

Susanna M. Nieminen,1* Riikka Kärki,2 Seppo Auriola,1 Mika Toivola,3 Hartmut Laatsch,4 Reino Laatikainen,5 Anne Hyvärinen,3 and Atte von Wright2

Department of Pharmaceutical Chemistry,1 Institute of Applied Biotechnology,2 Department of Chemistry, University of Kuopio, 70211 Kuopio,5 Division of Environmental Health, National Public Health Institute, 70701 Kuopio, Finland,3 Department of Organic Chemistry, University of Goettingen, Goettingen D-37077, Germany4

Received 14 February 2002/ Accepted 25 July 2002

Genotoxic and cytotoxic compounds were isolated and purified from the culture medium of an indoor air mold, Aspergillus fumigatus. One of these compounds was identified as gliotoxin, a known fungal secondary metabolite. Growth of A. fumigatus and gliotoxin production on some building materials were also studied. Strong growth of the mold and the presence of gliotoxin were detected on spruce wood, gypsum board, and chipboard under saturation conditions.

* Corresponding author. Mailing address: Institute of Applied Biotechnology, University of Kuopio, POB 1627, 70211 Kuopio, Finland. Phone: 358 17 163573. Fax: 358 17 163322. E-mail: susanna.nieminen{at}uku.fi.

Applied and Environmental Microbiology, October 2002, p. 4871-4875, Vol. 68, No. 10
0099-2240/02/$04.00+0     DOI: 10.1128/AEM.68.10.4871-4875.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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