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Applied and Environmental Microbiology, November 2002, p. 5769-5772, Vol. 68, No. 11
0099-2240/02/$04.00+0     DOI: 10.1128/AEM.68.11.5769-5772.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Regulation of freA, acoA, lysF, and cycA Expression by Iron Availability in Aspergillus nidulans

Harald Oberegger,1 Michelle Schoeser,1 Ivo Zadra,1,{dagger} Markus Schrettl,1 Walther Parson,2 and Hubertus Haas1*

Department of Molecular Biology,1 Institute of Legal Medicine, University of Innsbruck, A-6020 Innsbruck, Austria2

Received 3 June 2002/ Accepted 2 August 2002

In the filamentous fungus Aspergillus nidulans, iron homeostasis is regulated at the transcriptional level by the negative-acting GATA factor SREA. In this study the expression of a putative heme-containing metalloreductase-encoding gene, freA, was found to be upregulated by iron limitation independently of SREA, demonstrating the existence of an iron-regulatory mechanism which does not involve SREA. In contrast to freA, various other genes encoding proteins in need of iron-containing cofactors—acoA, lysF, and cycA—were downregulated in response to iron depletion. Remarkably, SREA deficiency led to increased expression of acoA, lysF, and cycA under iron-replete growth conditions.

* Corresponding author. Mailing address: Department of Molecular Biology, Fritz-Pregl-Str. 3/II, A-6020 Innsbruck, Austria. Phone: 43-512-507-3605. Fax: 43-512-507-2866. E-mail: hubertus.haas{at}uibk.ac.at.

{dagger} Present address: Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria.

Applied and Environmental Microbiology, November 2002, p. 5769-5772, Vol. 68, No. 11
0099-2240/02/$04.00+0     DOI: 10.1128/AEM.68.11.5769-5772.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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