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Regulation of freA, acoA, lysF, and cycA Expression by Iron Availability in Aspergillus nidulans

Harald Oberegger,¹ Michelle Schoeser,¹ Ivo Zadra,^1, Markus Schrettl,¹ Walther Parson,² and Hubertus Haas^1*

Department of Molecular Biology,¹ Institute of Legal Medicine, University of Innsbruck, A-6020 Innsbruck, Austria²

Received 3 June 2002/ Accepted 2 August 2002

In the filamentous fungus Aspergillus nidulans, iron homeostasis is regulated at the transcriptional level by the negative-acting GATA factor SREA. In this study the expression of a putative heme-containing metalloreductase-encoding gene, freA, was found to be upregulated by iron limitation independently of SREA, demonstrating the existence of an iron-regulatory mechanism which does not involve SREA. In contrast to freA, various other genes encoding proteins in need of iron-containing cofactors—acoA, lysF, and cycA—were downregulated in response to iron depletion. Remarkably, SREA deficiency led to increased expression of acoA, lysF, and cycA under iron-replete growth conditions.

Present address: Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria.

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