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Sakacin G, a New Type of Antilisterial Bacteriocin

Laboratoire de Microbiologie Fondamentale et Appliquée, EA 2224, IBMIG, 86022 Poitiers,¹ Rhodia Food, 86220 Dangé Saint-Romain, France²

Received 23 April 2002/ Accepted 2 September 2002

Sakacin G is a 37-amino-acid-residue-long class IIa bacteriocin produced by Lactobacillus sake 2512, which is encoded by the duplicated structural genes skgA1 and skgA2. Sakacin G appears to be unique and seems to be an intermediate between pediocin-like bacteriocins, according to its double-disulfide bridges required for antimicrobial activity, and mesentericin-like bacteriocins in terms of sequence homologies, inhibition spectrum, and specific activity.

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