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Applied and Environmental Microbiology, June 2002, p. 3166-3168, Vol. 68, No. 6
0099-2240/02/$04.00+0     DOI: 10.1128/AEM.68.6.3166-3168.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Oral Treatment with Lactococcus lactis Expressing Staphylococcus hyicus Lipase Enhances Lipid Digestion in Pigs with Induced Pancreatic Insufficiency

Sophie Drouault,1 Catherine Juste,1 Philippe Marteau,2 Pierre Renault,3 and Gérard Corthier1*

Unité d'Ecologie et de Physiologie du Systeme Digestif,1 Unité de Génétique Microbienne, Institut National de la Recherche Agronomique, 78350 Jouy en Josas,3 Service de Gastroentérologie, Hôpital G. Pompidou, 75908 Paris, France2

Received 3 October 2001/ Accepted 30 March 2002

The Staphylococcus hyicus lip gene was cloned in Lactococcus lactis. Pancreatic insufficiency was induced by ligation of the pancreatic duct in pigs. In pigs who had undergone pancreatic ligation, the coefficient of fat absorption was higher after consumption of lipase-expressing L. lactis (91.9% ± 3.7%) than that after consumption of the inactive control strain (78.4% ± 2.4%).

* Corresponding author. Mailing address: Unité d'Ecologie et de Physiologie du Systeme digestif, Institut National de la Recherche Agronomique, Batiment 440, 78352 Jouy en Josas Cedex, France. Phone: 33-1 34 65 24 67. Fax: 33-1 34 65 24 62. E-mail: corthier{at}jouy.inra.fr.

Applied and Environmental Microbiology, June 2002, p. 3166-3168, Vol. 68, No. 6
0099-2240/02/$04.00+0     DOI: 10.1128/AEM.68.6.3166-3168.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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