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Applied and Environmental Microbiology, July 2002, p. 3566-3569, Vol. 68, No. 7
0099-2240/02/$04.00+0     DOI: 10.1128/AEM.68.7.3566-3569.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Cardiovascular Effects of Fermented Milk Containing Angiotensin-Converting Enzyme Inhibitors Evaluated in Permanently Catheterized, Spontaneously Hypertensive Rats

Anders Fuglsang,1* Dan Nilsson,2 and Niels C. B. Nyborg3

Royal Danish School of Pharmacy, Institute of Pharmacology, 2100 Copenhagen Ø,1 Novo Nordisk A/S, 2670 Måløv,2 Chr. Hansen A/S, 2970 Hørsholm, Denmark3

Received 5 December 2001/ Accepted 19 April 2002

In this study, two strains of Lactobacillus helveticus were used to produce fermented milk rich in angiotensin-converting enzyme (ACE) inhibitors. In vitro tests revealed that the two milks contained competitive inhibitors of ACE in amounts comparable to what has been obtained in previously reported studies. The two milks were administered by gavage to spontaneously hypertensive rats that had had a permanent aortic catheter inserted through the left arteria carotis, and mean arterial blood pressure and heart rate were monitored from 4 to 8 h after administration. Unfermented milk and milk fermented with a lactococcal strain that does not produce inhibitors were used as controls. Highly significant blood pressure effects were observed; i.e., milk fermented with the two strains of L. helveticus gave a more pronounced drop in blood pressure than the controls. Significant differences in heart rate effects were detected with one of the strains.

* Corresponding author. Mailing address: Royal Danish School of Pharmacy, Institute of Pharmacology, Universitetsparken 2, 2100 Copenhagen Ø, Denmark. Phone 45 35306000. Fax: 45 35306020. E-mail: anfu{at}dfh.dk.

Applied and Environmental Microbiology, July 2002, p. 3566-3569, Vol. 68, No. 7
0099-2240/02/$04.00+0     DOI: 10.1128/AEM.68.7.3566-3569.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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