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Applied and Environmental Microbiology, January 2003, p. 186-190, Vol. 69, No. 1
0099-2240/03/$08.00+0     DOI: 10.1128/AEM.69.1.186-190.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Degradation of Anthracene by Mycobacterium sp. Strain LB501T Proceeds via a Novel Pathway, through o-Phthalic Acid

René van Herwijnen,1 Dirk Springael,2 Pieter Slot,1 Harrie A. J. Govers,1 and John R. Parsons1*

Department of Environmental and Toxicological Chemistry (IBED/MTC), University of Amsterdam, 1018WV Amsterdam, The Netherlands,1 Vlaamse Instelling voor Technologisch Onderzoek (Vito), B-2400 Mol, Belgium2

Received 29 April 2002/ Accepted 25 October 2002

Mycobacterium sp. strain LB501T utilizes anthracene as a sole carbon and energy source. We analyzed cultures of the wild-type strain and of UV-generated mutants impaired in anthracene utilization for metabolites to determine the anthracene degradation pathway. Identification of metabolites by comparison with authentic standards and transient accumulation of o-phthalic acid by the wild-type strain during growth on anthracene suggest a pathway through o-phthalic acid and protocatechuic acid. As the only productive degradation pathway known so far for anthracene proceeds through 2,3-dihydroxynaphthalene and the naphthalene degradation pathway to form salicylate, this indicates the existence of a novel anthracene catabolic pathway in Mycobacterium sp. LB501T.

* Corresponding author. Mailing address: Department of Environmental and Toxicological Chemistry (IBED/MTC), University of Amsterdam, Nieuwe Achtergracht 166, 1018WV Amsterdam, The Netherlands. Phone: 31(0)205256580. Fax: 31(0)205256522. E-mail: jparsons{at}science.uva.nl.

Applied and Environmental Microbiology, January 2003, p. 186-190, Vol. 69, No. 1
0099-2240/03/$08.00+0     DOI: 10.1128/AEM.69.1.186-190.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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Copyright © 2003 by the American Society for Microbiology. All rights reserved.