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Applied and Environmental Microbiology, November 2003, p. 6935-6937, Vol. 69, No. 11
0099-2240/03/$08.00+0     DOI: 10.1128/AEM.69.11.6935-6937.2003

FUM9 Is Required for C-5 Hydroxylation of Fumonisins and Complements the Meitotically Defined Fum3 Locus in Gibberella moniliformis

Robert A. E. Butchko,* Ronald D. Plattner, and Robert H. Proctor

National Center for Agricultural Resource Utilization, USDA Agricultural Research Service, Peoria, Illinois 61604

Received 23 June 2003/ Accepted 25 August 2003

Deletion of the Gibberella moniliformis FUM9 gene resulted in mutants that produce only fumonisins that lack a C-5 hydroxyl group. This phenotype is identical to that of previously described mutants with defective alleles at the meiotically defined Fum3 locus. Transformation with a wild-type FUM9 gene into a Fum3-defective mutant restored wild-type fumonisin production. These results indicate that the FUM9 protein catalyzes the C-5 hydroxylation of fumonisins and that FUM9 and the Fum3 locus are the same gene.

* Corresponding author. Mailing address: NCAUR-ARS-USDA, 1815 N. University St., Peoria, IL 61604. Phone (309) 681-6379. Fax: (309) 681-6689. E-mail: butchkora{at}ncaur.usda.gov.

Applied and Environmental Microbiology, November 2003, p. 6935-6937, Vol. 69, No. 11
0099-2240/03/$08.00+0     DOI: 10.1128/AEM.69.11.6935-6937.2003




This article has been cited by other articles:

  • Ding, Y., Bojja, R. S., Du, L. (2004). Fum3p, a 2-Ketoglutarate-Dependent Dioxygenase Required for C-5 Hydroxylation of Fumonisins in Fusarium verticillioides. Appl. Environ. Microbiol. 70: 1931-1934 [Abstract] [Full Text]  


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